薄膜中心主任

張    雍 講座教授

專業領域

  • 仿生材料科學
  • 薄膜分離工程
  • 精準醫療應用

 研究主題    

  • 仿生雙離子型材料於生物惰性功能控制與相關醫療器材應用研究
  • 智能型高分子薄膜之功能性敷料設計，應用於糖尿病傷口癒合研究
  • 建構人體血液成分精準分選科技於疾病控制之前瞻科研與尖端醫療之薄膜分離關鍵技術
  • 高分子生醫薄膜系統設計於白血球移除技術，應用於輸血安全研究
  • 超分子過濾系統於外泌體之分離、純化與回收，應用於疾病診斷研究
  • 微型過濾器設計與血液分離技術開發，應用於敗血症檢測研究
  • 溫感型薄膜系統於血小板回收與蛋白質生長因子純化，應用於關節炎治療研究
  • 奈米纖維薄膜系統於淋巴球之分離、純化與回收，應用於免疫治療研究

 學術專長    

  • 量子物理化學
  • 高分子聚合科學
  • 雙離子材料科學
  • 智能型醫療器材

技術專長    

  • 表面改質技術
  • 薄膜工程技術
  • 生化分離技術
  • 血液淨化技術
  • 精準醫療技術

 榮譽 / 獲獎     

  • 斐陶斐榮譽學會『傑出成就獎』(2025)
  • 經濟部『國家產業創新獎』(2025)
  • 中華民國高分子學會『傑出高分子應用獎』(2025)
  • 國科會『傑出研究獎』(2024)
  • 中國工程師學會『傑出工程教授獎』(2024)
  • 行政院『傑出科技貢獻獎』(2023)
  • 中華民國高分子學會『傑出高分子學術研究獎』(2023)
  • 東元科技文教基金會『東元科技獎』(2023)
  • 經濟部『國家發明獎 』(2021)
  • 經濟部『國家發明創作獎』(2020)
  • 台灣化學工程學會『化工技術獎』(2020)
  • 日本化學工程學會『亞洲化學工程國際研究傑出獎』(2018)
  • 國際發明學會『發明專利終身成就獎』(2016)
  • 國科會『吳大猷先生紀念獎』(2013)
  • 中華民國高分子學會『年輕研究學者獎』(2011)
  • 台灣化學工程學會『學術勵進獎』(2010)

2025年 經濟部 『國家產業創新獎』

2023年 行政院『傑出科技貢獻獎』

2023年東元文教基金會『東元科技獎』

學術著作 (SCI papers : 300+; Citations: 14,000; h-index: 66)

  1. Ryohei Kakuchi, Takuma Oguchi, Masaaki Omichi, Noriaki Seko, Gian Vincent Dizon, Yung Chang *, Hikaru Yanai (2026) “A New Class of Zwitterionic Polymers Featuring Carbon-Centered Anions”, Macromolecules, 2026, 59, 5, 2698–2705 (Impact Factor: 5.2) (Graduate student supervised: Takuma Oguchi) (Published Date: 2026/2/17)
  2. Antoine Venault, Yuan-Chen Huang, Yung Chang* (2025) “Carbon black-modified polyvinylidene fluoride vapor-induced phase separation membranes for effective direct contact membrane distillation”, Journal of Membrane Science, 732, 124262. (Impact Factor: 9.0) (Graduate student supervised: Yuan-Chen Huang) (Published Date: 2025/5/26)
  3. Chih-Chen Yeh, Antoine Venault, Gian Vincent Dizon, Pin-Rong Lin, Kai-Lin Liang, Shih-Hong Liou, Chung-Jung Chou, Patrice Bacchin, Yung Chang* (2025) “Forward osmosis zwitterionic membranes for platelet concentration – Evaluation of the feasibility of the concept”, Separation and Purification Technology, 354, 129013 (Impact Factor: 9.0) (Graduate student supervised: Chih-Chen Yeh, Pin-Rong Lin, Kai-Lin Liang, Shih-Hong Liou) (Published Date: 2024/7/28)
  4. Irish Valerie Maggay, Ying-Tzu Chiu, Hao-Tung Lin, Antoine Venault, Yung Chang* (2025) “Engineering bio-inert and thermostable poly(vinylidene difluoride) membranes by grafting thermal-tolerant copolymers via ring-opening reaction”, Journal of Membrane Science Letters, 5, 100088. (Impact Factor: 4.7) (Graduate student supervised: Ying-Tzu Chiu, Hao-Tung Lin) (Published Date: 2024/11/24)
  5. Antoine Venault, Bo-Cheng Wu, Yung Chang* (2025) “ Ring-opening reaction of maleic anhydride with an amino-end derivative of sulfobetaine methacrylate for effective, versatile and stable fabrication of bacteria and blood-resistant porous polymeric films”, Journal of the Taiwan Institute of Chemical Engineers, 168, 105947. (Impact Factor: 6.3) (Graduate student supervised: Bo-Cheng Wu) (Published Date: 2025/1/3)
  6. Gian Vincent Canlas Dizon, Chiao-Ling Chang, Chih-Chen Yeh, Chung-Jung Chou, Jheng-Fong Jhong, Jie Zheng, Yung Chang* (2025) “ Bioinert Fibrous Polypropylene Membranes via In Situ Polymerization of Zwitterionic Poly(sulfobetaine methacrylate)”, Langmuir, 41, 4524−4532. (Impact Factor: 3.9) (Graduate student supervised: Chiao-Ling Chang, Chih-Chen Yeh) (Published Date: 2025/2/10)
  7. Gian Vincent Dizon, Yu-Jen Huang, Fang-Cheng Lin, Irish Valerie Maggay, Yung Chang*, Antoine Venault (2025) “Assessment of the Blood Separation Performances of Asymmetric Cellulose Acetate Membranes Prepared through Combined Vapor- Induced Phase Separation and Electrospinning”, ACS Appl. Mater. Interfaces, 17, 31923−31940. (Impact Factor: 8.2) (Graduate student supervised: Yu-Jen Huang, Fang-Cheng Lin) (Published Date: 2025/5/20)
  8. Trisha Nicole Lazo, Irish Valerie Maggay, Lemmuel Tayo, Yung Chang*, Antoine Venault (2025) “Achieving antibiofouling on microporous membranes prepared with a green solvent via spraying an aqueous antifouling copolymer solution”, Journal of Membrane Science, 715, 123499. (Impact Factor: 9.0) (Graduate student supervised: Trisha Nicole Lazo) (Published Date: 2024/11/12)
  9. Antoine Venault , Ren-Min Lai , Irish Valerie Maggay , Shih-Hong Liou , Yung Chang * (2024) “A green zwitterionic bi-continuous membranes prepared by dual-bath procedure for mitigating biofouling during bacterial removal from water”, Journal of Membrane Science, 710, 123166. (Impact Factor: 9.0) (Graduate student supervised:：Ren-Min Lai, Shih-Hong Liou) (Published Date: 2024/8/5)
  10. Antoine Venault, Bo-Cheng Wu, Irish Valerie Maggay, Yung Chang* (2024) “Unlocking the potential of zwitterionic vapor-induced phase separation membranes synthesized from maleic anhydride in polyvinylidene fluoride-based systems for antifouling applications”, Journal of Membrane Science, 708, 123076. (Impact Factor: 9.0) (Graduate student supervised: Bo-Cheng Wu) (Published Date: 2024/7/7)
  11. Antoine Venault, Yi-Ling Wu, Irish Valerie Maggay, Yung Chang* (2024) “Rapid attainment of full wettability through surface PEGylation of hydrophobic polyvinylidene fluoride membranes via spray-coating for enhanced anti-biofouling performances”, Separation and Purification Technology, 349, 127917. (Impact Factor: 9.0) (Graduate student supervised: Yi-Ling Wu) (Published Date: 2024/5/10)
  12. Antoine Venault, Yi-Ling Wu, Wen Xin Yen, Yung Chang* (2024) “A green bulk modification for imparting a green VIPS membrane with antifouling properties”, Journal of the Taiwan Institute of Chemical Engineers, 165, 105731 (Impact Factor: 6.3) (Graduate student supervised: Yi-Ling Wu, Wen Xin Yen) (Published Date: 2024/8/29)
  13. Kang-Ting Huang, Cao Tuong Vi Nguyen, Pin-Ju Yu, Cheng-Lin Lee, Chun-Jen Huang, Yung Chang* (2024) “Incorporation of polyzwitterions in superabsorbent network membranes for enhanced saltwater absorption and retention”, Journal of Membrane Science Letters, 4, 100083 (Impact Factor: 4.7) (Graduate student supervised: Kang-Ting Huang, Cao Tuong Vi Nguyen) (Published Date: 2024/8/31)
  14. Chih-Ling Lee, Cao-An Vu, Van-Truc Vu, Chao-Min Cheng, Yung Chang*, Wen-Yih Chen (2024) “Integrating Sulfobetaine Methacrylate Hydrogel-Modified Cellulose Triacetate Filter into a Zwitterionized Tandem Membrane System for Exosome Isolation”, ACS Appl. Polym. Mater., 6, 2741−2751 (Impact Factor: 4.8) (Graduate student supervised: Chih-Ling Lee, Cao-An Vu, Van-Truc Vu, Chao-Min Cheng) (Published Date: 2024/2/27)
  15. Antoine Venault, Yung-Chih Chen, Shuo-Hsi Tang, Ta-Chin Wei, Ching-Fu Weng, Patrice Bacchin, Yung Chang* (2023) “Surface zwitterionization of polypropylene nonwoven fabric by dielectric barrier discharge plasma for efficient leukodepletion”, Journal of Membrane Science, 683, 121803. (Impact Factor: 9.0) (Graduate student supervised: Yung-Chih Chen, Shuo-Hsi Tang) (Published Date: 2023/6/2)
  16. Antoine Venault , Kuo-Yun Chang, Irish Valerie Maggay, Yung Chang* (2023) “Assessment of the DCMD performances of poly(vinylidene difluoride) vapor-induced phase separation membranes with adjusted wettability via formation process parameter manipulation”, Desalination, 560, 116682. (Impact Factor: 9.8) (Graduate student supervised: Kuo-Yun Chang) (Published Date: 2023/5/13)
  17. Antoine Venault, Shuo-Hsi Tang, Hsiu-Fang Lin, Cheng-Liang Liu, Yung Chang* (2023) “Spray-coating of a hydrophobic poly(tetrafluoroethylene) membrane with a copolymer containing sulfobetaine methacrylamide to boost hydration and reduce biofouling in view of improving diabetic wound management and alleviate the immune response”, Journal of Membrane Science, 685, 121962 (Impact Factor: 9.0) (Graduate student supervised:：Shuo-Hsi Tang, Hsiu-Fang Lin) (Published Date: 2023/8/2)
  18. Antoine Venault, Tesfaye Abebe Geleta, Tai-Yi Chiu, Hao-Tung Lin, Irish Valerie Maggay, Yung Chang* (2023) “A copolymer derivative of poly(4-vinylpyridine propylsulfobetaine) for the design of thermostable bioinert poly(vinylidene difluoride) microporous membranes by vapor-induced phase separation”, Separation and Purification Technology, 325, 124686 (Impact Factor: 9.0) (Graduate student supervised:：Tai-Yi Chiu, Hao-Tung Lin) (Published Date: 2023/7/28)
  19. Shuo-Hsi Tang, Antoine Venault, Yi-Hsin Liu, Yung Chang* (2023) “Blood compatible, fog-, frost- and bacterial-resistant dopamine-enabled zwitterionic glass interfaces”, Journal of the Taiwan Institute of Chemical Engineers, 146, 104858. (Impact Factor: 6.3) (Graduate student supervised: Shuo-Hsi Tang, Yi-Hsin Liu) (Published Date: 2023/4/12)
  20. Irish Valerie Maggay, Ting-Yu Liao, Antoine Venault, Hao-Tung Lin, Chih-Cheng Chao, Ta-Chin Wei, Yung Chang* (2023) “Leveraging the Dielectric Barrier Discharge Plasma Process to Create Regenerative Biocidal ePTFE Membranes”, ACS Appl. Mater. Interfaces, 15, 48001−48014. (Impact Factor: 8.2) (Graduate student supervised: Ting-Yu Liao, Hao-Tung Lin, Chih-Cheng Chao) (Published Date: 2023/10/3)
  21. Yung Chang* (2022) “Designs of zwitterionic polymers”. Journal of Polymer Research, 29(7), 286 (Impact Factor: 2.9) (Published Date: 2022/6/22)
  22. Irish Valerie Maggay, Antoine Venault, Chi-Yao Fang, Cheng-Chen Yang, Chen-Hua Hsu, Chih-Yu Chou, Kazuhiko Ishihara, Yung Chang* (2021)“Zwitterionized Nanofibrous Poly(vinylidene fluoride) Membranes for Improving the Healing of Diabetic Wounds”, ACS Biomaterials Science and Engineering, 7(2), 562-5 (Impact Factor: 5.5) (Graduate student supervised:：Irish Valerie Maggay, Chi-Yao Fang, Cheng-Chen Yang, Chen-Hua Hsu, Chih-Yu Chou) (Published Date: 2021/1/15)
  23. Peter Matthew Paul T. Fowler, Gian Vincent Dizon, Lemmuel L. Tayo, Alvin R. Caparanga, James Huang, Jie Zheng, Pierre Aimar, Yung Chang* (2020)“Surface Zwitterionization of Expanded Poly(tetrafluoroethylene) via Dopamine-Assisted Consecutive Immersion Coating”, ACS Applied Materials & Interfaces, 12 (37), 41000-41010. (Impact Factor: 8.2) (Graduate student supervised:：Peter Matthew Paul T. Fowler, Gian Vincent Dizon) (Published Date: 2020/8/21)

發明專利

  • US Patents: (美國發明專利)
  1. Super-low fouling sulfobetaine and carboxybetaine materials and related methods (超低汙染之磺基甜菜鹼與羧基甜菜鹼材料及其相關方法), Patent Number: US7879444B2, Issue Date: 2011-02-01
  2. Low biofouling filtration membranes and their forming method (低生物汙染之過濾膜及其製備方法), Patent Number: US8062751B2, Issue Date: 2011-11-22
  3. Antibiofouling nonionic-zwitterionic copolymer (抗生物汙染之非離子—雙離子共聚物), Patent Number: US8288472B2, Issue Date: 2012-10-16
  4. Super-low fouling sulfobetaine materials and related methods (超低汙染之磺基甜菜鹼材料及其相關方法), Patent Number: US8545983B2, Issue Date: 2013-10-01
  5. Surface anti-biomolecule agent (表面抗生物分子劑), Patent Number: US8933173B2, Issue Date: 2015-01-13
  6. Dental care product (口腔護理產品), Patent Number: US8980232B2, Issue Date: 2015-03-17
  7. Zwitterionic-bias material for blood cell selection (用於血球選擇之雙離子偏差材料), Patent Number: US9034932B1, Issue Date: 2015-05-19
  8. Microfluid testing system with a multiple-channel disc and utility thereof (具多通道圓盤之微流體檢測系統及其用途), Patent Number: US9091699B2, Issue Date: 2015-07-28
  9. Dental care product with two-part formulations and utility thereof (雙配方之口腔護理產品及其用途), Patent Number: US9254255B2, Issue Date: 2016-02-09
  10. Antibiofouling composition, antibiofouling membrane and method for forming the same (抗生物汙染組成物、抗生物汙染膜及其製造方法), Patent Number: US9346022B2, Issue Date: 2016-05-24
  11. Biocarrier and method of using the same (生物載體及其使用方法), Patent Number: US9393194B2, Issue Date: 2016-07-19
  12. Amine modifying material and application thereof (胺基改質材料及其應用), Patent Number: US9522971B2, Issue Date: 2016-12-20
  13. Particles coated with zwitterionic polymers comprising sulfobetaine or carboxybetaine (包覆含磺基甜菜鹼或羧基甜菜鹼之雙離子聚合物的粒子), Patent Number: US9598544B2, Issue Date: 2017-03-21
  14. Polymer and device for capturing or separating leucocytes, manufacturing method and use thereof (捕捉或分離白血球之聚合物與裝置、其製造方法及用途), Patent Number: US11833289B2, Issue Date: 2023-12-05
  15. Platelet filtration membrane and its applications thereof (血小板過濾膜及其應用), Patent Number: US12274987B2, Issue Date: 2025-04-15
  • Taiwan Patents: (台灣發明專利)
  1. Super-low fouling carboxybetaine materials and related methods (超低汙染之羧基甜菜鹼材料及其相關方法), Patent Number: TWI330657B, Issue Date: 2010-09-21
  2. Method for Surface Modification of Substrate (基材表面改質方法), Patent Number: TWI400285B, Issue Date: 2013-07-01
  3. Leukocyte filter material and filter method thereof (白血球過濾材料及其過濾方法), Patent Number: TWI410269B, Issue Date: 2013-10-01
  4. Low biofouling filtration membranes and their forming method (低生物汙染之過濾膜及其製備方法), Patent Number: TWI423843B, Issue Date: 2014-01-21
  5. Wound healing scaffold and method for fabricating the same (傷口癒合支架及其製造方法), Patent Number: TWI423829B, Issue Date: 2014-01-21
  6. Skin Wound Healing Material and Method for Manufacturing the Same (皮膚傷口癒合材料及其製造方法), Patent Number: TWI425959B, Issue Date: 2014-02-11
  7. Dental care product (口腔護理產品), Patent Number: TWI428150B, Issue Date: 2014-03-01
  8. Blood Filtering Device (血液過濾裝置), Patent Number: TWM477285U, Issue Date: 2014-05-01
  9. Antibiofouling nonionic-zwitterionic copolymer (抗生物汙染之非離子—雙離子共聚物), Patent Number: TWI452051B, Issue Date: 2014-09-11
  10. Antibiofouling composition, antibiofouling membrane and method for forming the same (抗生物汙染組成物、抗生物汙染膜及其製造方法), Patent Number: TWI496853B, Issue Date: 2015-08-21
  11. Biomimetic agent for anti-biofouling coating and method for making the same (用於抗生物汙染塗層之仿生試劑及其製造方法), Patent Number: TWI496819B, Issue Date: 2015-08-21
  12. Testing microfluid system with a multiple-channel disc and utility thereof (具多通道圓盤之微流體檢測系統及其用途), Patent Number: TWI509066B, Issue Date: 2015-11-21
  13. Antifouling Membranes for Water Treatment Application Thereof (抗汙薄膜於水處理之應用), Patent Number: TWI522161B, Issue Date: 2016-02-21
  14. Surface anti-biomolecule agent (表面抗生物分子劑), Patent Number: TWI541032B, Issue Date: 2016-07-11
  15. Amine modifying material and application thereof (胺基改質材料及其應用), Patent Number: TWI549974B, Issue Date: 2016-09-21
  16. A method for blood cell selection (血球選擇方法), Patent Number: TWI559971B, Issue Date: 2016-12-01
  17. Stem Cell Culture Device, Method of Fabrication, and Method for Partial Detachment of Stem Cells (幹細胞培養裝置、其製造方法與幹細胞部分剝離方法), Patent Number: TWI602915B, Issue Date: 2017-10-21
  18. Polymer and device for capturing or separating leucocytes, manufacturing method and use thereof (捕捉或分離白血球之聚合物與裝置、其製造方法及用途), Patent Number: TWI661864B, Issue Date: 2019-06-11
  19. A Bio-inert Material and its Application in a Method for Reducing Biomolecular Adsorption on Metal Surfaces (生物惰性材料及其在降低金屬表面生物分子吸附方法中的應用), Patent Number: TWI800039B, Issue Date: 2023-04-21
  20. Thermo-induced stimuli-responsive membrane for leukocyte enrichment and application thereof (用於白血球富集之熱感應刺激回應膜及其應用), Patent Number: TWI871196B, Issue Date: 2025-01-21
  • Europe Patents (歐盟發明專利)
  1. Super-low fouling sulfobetaine and carboxybetaine materials and related methods (超低汙染之磺基甜菜鹼與羧基甜菜鹼材料及其相關方法), Patent Number: EP1924654B1, Issue Date: 2020-05-06
  2. Double-ion charge deviation-type material for blood cell screening and method for removing leukocytes from blood sample (用於血球篩選之雙離子電荷偏差型材料及自血液樣本移除白血球之方法), Patent Number: EP3095502B1, Issue Date: 2021-01-20
  • Japan Patents (日本發明專利)
  1. Ultra-low fouling sulfobetaine and carboxybetaine materials and related methods (超低汙染之磺基甜菜鹼與羧基甜菜鹼材料及其相關方法), Patent Number: JP6085075B2, Issue Date: 02/22/2011
  2. Double-ion charge deviation-type material for blood cell screening and method for removing leukocytes from blood sample (用於血球篩選之雙離子電荷偏差型材料及自血液樣本移除白血球之方法), Patent Number: JP6457627B2, Issue Date: 2019-01-23
  • China Patents (中國發明專利)
  1. Leukocyte filter material and filter method thereof (白血球過濾材料及其過濾方法), Patent Number: CN102397724B, Issue Date: 2014-08-20
  2. Microfluid testing system with a multiple-channel disc and utility thereof (具多通道圓盤之微流體檢測系統及其用途), Patent Number: CN103913562B, Issue Date: 2016-06-29
  3. Polymer and device for capturing or separating leucocytes, manufacturing method and use thereof (聚合物與用於捕捉或分離白血球之裝置、其製造方法及用途), Patent Number: CN109963600B, Issue Date: 2023-01-06

 

技術授權

  1. 高感度病毒捕捉技術
  2. 白血球分離技術
  3. 抗生物分子表面沾黏技術
  4. 不鏽鋼導引線表面聚烯塗層技術
  5. 醫藥級覆膜丁基膠塞技術
  6. 奈米纖維素於止血材技術
  7. 抗沾黏共聚物組成與製造技術
  8. 醫療級高分子薄膜於血小板衍生生長因子分離純化技術
  9. 仿生保濕薄膜材料技術
  10. 薄膜關鍵原料開發技術
  11. 分離白血球之材料、方法、材料製造方法、過濾器及其用途
  12. 血液淨化技術
  13. 傷口敷料技術
  14. 薄膜功能化塗佈技術
  15. 雙離子性氟素材於傷口癒合技術
  16. 雙親性鐵氟龍創傷敷料技術
  17. 多孔性氟素材於傷口癒合技術
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