CMT Director

Chair Professor Yung CHANG

  • Degree: Ph.D. in Chemical Engineering, National Taiwan University
  • E-mail: ychang@cycu.edu.tw, changyung0307@gmail.com
  • Current Position: Chair Professor, Department of Chemical Engineering, Chung Yuan Christian University

Fields of Expertise

  • Biomimetic Materials Science
  • Membrane Separation Engineering
  • Precision Medicine Applications

Research Fields & Topics

  • Biomimetic zwitterionic materials for bio-inert functional control and related medical device applications  
  • Functional dressing design based on smart polymeric membranes for diabetes wound healing research
  • Development of precision sorting technologies for human blood components to advance disease control and cutting-edge membrane separation medical technologies
  • Polymeric biomedical membrane system design for leukocyte depletion technology applied to blood transfusion safety
  • Supramolecular filtration systems for the isolation, purification, and recovery of exosomes applied to disease diagnosis
  • Micro-filter design and blood separation technology development applied to sepsis detection
  • Thermo-responsive membrane systems for platelet recovery and protein growth factor purification applied to arthritis treatment
  • Nanofibrous membrane systems for the isolation, purification, and recovery of lymphocytes applied to immunotherapy

Academic Specialization

  • Quantum Physical Chemistry
  • Polymerization Science
  • Zwitterionic Materials Science
  • Smart Medical Devices

Technical Specialization

  • Surface Modification Technology
  • Membrane Engineering Technology
  • Biochemical Separation Technology
  • Blood Purification Technology
  • Precision Medical Technology

Honors & Awards

  • 2025: Outstanding Achievement Award, The Phi Tau Phi Scholastic Honor Society
  • 2025: National Industrial Innovation Award, Ministry of Economic Affairs
  • 2025: Outstanding Polymer Application Award, The Polymer Society of Taipei
  • 2024: Outstanding Research Award, National Science and Technology Council (NSTC)
  • 2024: Outstanding Engineering Professor Award, Chinese Institute of Engineers
  • 2023: Executive Yuan Award for Outstanding Contribution in Science and Technology
  • 2023: Outstanding Polymer Academic Research Award, The Polymer Society of Taipei
  • 2023: TECO Award, TECO Technology Foundation
  • 2021: National Invention Award, Ministry of Economic Affairs
  • 2020: National Invention and Creation Award, Ministry of Economic Affairs
  • 2020: Chemical Engineering Technology Award, Taiwan Institute of Chemical Engineers
  • 2018: Outstanding International Research Award for Asian Chemical Engineering, The Society of Chemical Engineers, Japan (SCEJ)
  • 2016: Lifetime Achievement Award for Invention Patents, International Invention Society
  • 2013: Ta-You Wu Memorial Award, National Science and Technology Council (NSTC)
  • 2011: Young Scholar Award, The Polymer Society of Taipei
  • 2010: Academic Encouragement Award, Taiwan Institute of Chemical Engineers

2025: National Industrial Innovation Award, Ministry of Economic Affairs

2023: Executive Yuan Award for Outstanding Contribution in Science and Technology

2023: TECO Award, TECO Technology Foundation

Academic Publications (SCI papers : 300+; Citations: 14,000; h-index: 66)

  1. Ryohei Kakuchi, Takuma Oguchi, Masaaki Omichi, Noriaki Seko, Gian Vincent Dizon, Yung Chang *, Hikaru Yanai (2026) “A New Class of Zwitterionic Polymers Featuring Carbon-Centered Anions”, Macromolecules, 2026, 59, 5, 2698–2705 (Impact Factor: 5.2) (Graduate student supervised: Takuma Oguchi) (Published Date: 2026/2/17)
  2. Antoine Venault, Yuan-Chen Huang, Yung Chang* (2025) “Carbon black-modified polyvinylidene fluoride vapor-induced phase separation membranes for effective direct contact membrane distillation”, Journal of Membrane Science, 732, 124262. (Impact Factor: 9.0) (Graduate student supervised: Yuan-Chen Huang) (Published Date: 2025/5/26)
  3. Chih-Chen Yeh, Antoine Venault, Gian Vincent Dizon, Pin-Rong Lin, Kai-Lin Liang, Shih-Hong Liou, Chung-Jung Chou, Patrice Bacchin, Yung Chang* (2025) “Forward osmosis zwitterionic membranes for platelet concentration – Evaluation of the feasibility of the concept”, Separation and Purification Technology, 354, 129013 (Impact Factor: 9.0) (Graduate student supervised: Chih-Chen Yeh, Pin-Rong Lin, Kai-Lin Liang, Shih-Hong Liou) (Published Date: 2024/7/28)
  4. Irish Valerie Maggay, Ying-Tzu Chiu, Hao-Tung Lin, Antoine Venault, Yung Chang* (2025) “Engineering bio-inert and thermostable poly(vinylidene difluoride) membranes by grafting thermal-tolerant copolymers via ring-opening reaction”, Journal of Membrane Science Letters, 5, 100088. (Impact Factor: 4.7) (Graduate student supervised: Ying-Tzu Chiu, Hao-Tung Lin) (Published Date: 2024/11/24)
  5. Antoine Venault, Bo-Cheng Wu, Yung Chang* (2025) “ Ring-opening reaction of maleic anhydride with an amino-end derivative of sulfobetaine methacrylate for effective, versatile and stable fabrication of bacteria and blood-resistant porous polymeric films”, Journal of the Taiwan Institute of Chemical Engineers, 168, 105947. (Impact Factor: 6.3) (Graduate student supervised: Bo-Cheng Wu) (Published Date: 2025/1/3)
  6. Gian Vincent Canlas Dizon, Chiao-Ling Chang, Chih-Chen Yeh, Chung-Jung Chou, Jheng-Fong Jhong, Jie Zheng, Yung Chang* (2025) “ Bioinert Fibrous Polypropylene Membranes via In Situ Polymerization of Zwitterionic Poly(sulfobetaine methacrylate)”, Langmuir, 41, 4524−4532. (Impact Factor: 3.9) (Graduate student supervised: Chiao-Ling Chang, Chih-Chen Yeh) (Published Date: 2025/2/10)
  7. Gian Vincent Dizon, Yu-Jen Huang, Fang-Cheng Lin, Irish Valerie Maggay, Yung Chang*, Antoine Venault (2025) “Assessment of the Blood Separation Performances of Asymmetric Cellulose Acetate Membranes Prepared through Combined Vapor- Induced Phase Separation and Electrospinning”, ACS Appl. Mater. Interfaces, 17, 31923−31940. (Impact Factor: 8.2) (Graduate student supervised: Yu-Jen Huang, Fang-Cheng Lin) (Published Date: 2025/5/20)
  8. Trisha Nicole Lazo, Irish Valerie Maggay, Lemmuel Tayo, Yung Chang*, Antoine Venault (2025) “Achieving antibiofouling on microporous membranes prepared with a green solvent via spraying an aqueous antifouling copolymer solution”, Journal of Membrane Science, 715, 123499. (Impact Factor: 9.0) (Graduate student supervised: Trisha Nicole Lazo) (Published Date: 2024/11/12)
  9. Antoine Venault , Ren-Min Lai , Irish Valerie Maggay , Shih-Hong Liou , Yung Chang * (2024) “A green zwitterionic bi-continuous membranes prepared by dual-bath procedure for mitigating biofouling during bacterial removal from water”, Journal of Membrane Science, 710, 123166. (Impact Factor: 9.0) (Graduate student supervised:：Ren-Min Lai, Shih-Hong Liou) (Published Date: 2024/8/5)
  10. Antoine Venault, Bo-Cheng Wu, Irish Valerie Maggay, Yung Chang* (2024) “Unlocking the potential of zwitterionic vapor-induced phase separation membranes synthesized from maleic anhydride in polyvinylidene fluoride-based systems for antifouling applications”, Journal of Membrane Science, 708, 123076. (Impact Factor: 9.0) (Graduate student supervised: Bo-Cheng Wu) (Published Date: 2024/7/7)
  11. Antoine Venault, Yi-Ling Wu, Irish Valerie Maggay, Yung Chang* (2024) “Rapid attainment of full wettability through surface PEGylation of hydrophobic polyvinylidene fluoride membranes via spray-coating for enhanced anti-biofouling performances”, Separation and Purification Technology, 349, 127917. (Impact Factor: 9.0) (Graduate student supervised: Yi-Ling Wu) (Published Date: 2024/5/10)
  12. Antoine Venault, Yi-Ling Wu, Wen Xin Yen, Yung Chang* (2024) “A green bulk modification for imparting a green VIPS membrane with antifouling properties”, Journal of the Taiwan Institute of Chemical Engineers, 165, 105731 (Impact Factor: 6.3) (Graduate student supervised: Yi-Ling Wu, Wen Xin Yen) (Published Date: 2024/8/29)
  13. Kang-Ting Huang, Cao Tuong Vi Nguyen, Pin-Ju Yu, Cheng-Lin Lee, Chun-Jen Huang, Yung Chang* (2024) “Incorporation of polyzwitterions in superabsorbent network membranes for enhanced saltwater absorption and retention”, Journal of Membrane Science Letters, 4, 100083 (Impact Factor: 4.7) (Graduate student supervised: Kang-Ting Huang, Cao Tuong Vi Nguyen) (Published Date: 2024/8/31)
  14. Chih-Ling Lee, Cao-An Vu, Van-Truc Vu, Chao-Min Cheng, Yung Chang*, Wen-Yih Chen (2024) “Integrating Sulfobetaine Methacrylate Hydrogel-Modified Cellulose Triacetate Filter into a Zwitterionized Tandem Membrane System for Exosome Isolation”, ACS Appl. Polym. Mater., 6, 2741−2751 (Impact Factor: 4.8) (Graduate student supervised: Chih-Ling Lee, Cao-An Vu, Van-Truc Vu, Chao-Min Cheng) (Published Date: 2024/2/27)
  15. Antoine Venault, Yung-Chih Chen, Shuo-Hsi Tang, Ta-Chin Wei, Ching-Fu Weng, Patrice Bacchin, Yung Chang* (2023) “Surface zwitterionization of polypropylene nonwoven fabric by dielectric barrier discharge plasma for efficient leukodepletion”, Journal of Membrane Science, 683, 121803. (Impact Factor: 9.0) (Graduate student supervised: Yung-Chih Chen, Shuo-Hsi Tang) (Published Date: 2023/6/2)
  16. Antoine Venault , Kuo-Yun Chang, Irish Valerie Maggay, Yung Chang* (2023) “Assessment of the DCMD performances of poly(vinylidene difluoride) vapor-induced phase separation membranes with adjusted wettability via formation process parameter manipulation”, Desalination, 560, 116682. (Impact Factor: 9.8) (Graduate student supervised: Kuo-Yun Chang) (Published Date: 2023/5/13)
  17. Antoine Venault, Shuo-Hsi Tang, Hsiu-Fang Lin, Cheng-Liang Liu, Yung Chang* (2023) “Spray-coating of a hydrophobic poly(tetrafluoroethylene) membrane with a copolymer containing sulfobetaine methacrylamide to boost hydration and reduce biofouling in view of improving diabetic wound management and alleviate the immune response”, Journal of Membrane Science, 685, 121962 (Impact Factor: 9.0) (Graduate student supervised:：Shuo-Hsi Tang, Hsiu-Fang Lin) (Published Date: 2023/8/2)
  18. Antoine Venault, Tesfaye Abebe Geleta, Tai-Yi Chiu, Hao-Tung Lin, Irish Valerie Maggay, Yung Chang* (2023) “A copolymer derivative of poly(4-vinylpyridine propylsulfobetaine) for the design of thermostable bioinert poly(vinylidene difluoride) microporous membranes by vapor-induced phase separation”, Separation and Purification Technology, 325, 124686 (Impact Factor: 9.0) (Graduate student supervised:：Tai-Yi Chiu, Hao-Tung Lin) (Published Date: 2023/7/28)
  19. Shuo-Hsi Tang, Antoine Venault, Yi-Hsin Liu, Yung Chang* (2023) “Blood compatible, fog-, frost- and bacterial-resistant dopamine-enabled zwitterionic glass interfaces”, Journal of the Taiwan Institute of Chemical Engineers, 146, 104858. (Impact Factor: 6.3) (Graduate student supervised: Shuo-Hsi Tang, Yi-Hsin Liu) (Published Date: 2023/4/12)
  20. Irish Valerie Maggay, Ting-Yu Liao, Antoine Venault, Hao-Tung Lin, Chih-Cheng Chao, Ta-Chin Wei, Yung Chang* (2023) “Leveraging the Dielectric Barrier Discharge Plasma Process to Create Regenerative Biocidal ePTFE Membranes”, ACS Appl. Mater. Interfaces, 15, 48001−48014. (Impact Factor: 8.2) (Graduate student supervised: Ting-Yu Liao, Hao-Tung Lin, Chih-Cheng Chao) (Published Date: 2023/10/3)
  21. Yung Chang* (2022) “Designs of zwitterionic polymers”. Journal of Polymer Research, 29(7), 286 (Impact Factor: 2.9) (Published Date: 2022/6/22)
  22. Irish Valerie Maggay, Antoine Venault, Chi-Yao Fang, Cheng-Chen Yang, Chen-Hua Hsu, Chih-Yu Chou, Kazuhiko Ishihara, Yung Chang* (2021)“Zwitterionized Nanofibrous Poly(vinylidene fluoride) Membranes for Improving the Healing of Diabetic Wounds”, ACS Biomaterials Science and Engineering, 7(2), 562-5 (Impact Factor: 5.5) (Graduate student supervised:：Irish Valerie Maggay, Chi-Yao Fang, Cheng-Chen Yang, Chen-Hua Hsu, Chih-Yu Chou) (Published Date: 2021/1/15)
  23. Peter Matthew Paul T. Fowler, Gian Vincent Dizon, Lemmuel L. Tayo, Alvin R. Caparanga, James Huang, Jie Zheng, Pierre Aimar, Yung Chang* (2020)“Surface Zwitterionization of Expanded Poly(tetrafluoroethylene) via Dopamine-Assisted Consecutive Immersion Coating”, ACS Applied Materials & Interfaces, 12 (37), 41000-41010. (Impact Factor: 8.2) (Graduate student supervised:：Peter Matthew Paul T. Fowler, Gian Vincent Dizon) (Published Date: 2020/8/21)

Invention Patents

  • US Patents
  1. US7879444B2: Super-low fouling sulfobetaine and carboxybetaine materials and related methods (Issue Date: 2011-02-01)
  2. US8062751B2: Low biofouling filtration membranes and their forming method (Issue Date: 2011-11-22)
  3. US8288472B2: Antibiofouling nonionic-zwitterionic copolymer (Issue Date: 2012-10-16)
  4. US8545983B2: Super-low fouling sulfobetaine materials and related methods (Issue Date: 2013-10-01)
  5. US8933173B2: Surface anti-biomolecule agent (Issue Date: 2015-01-13)
  6. US8980232B2: Dental care product (Issue Date: 2015-03-17)
  7. DOCX
  8. US9034932B1: Zwitterionic-bias material for blood cell selection (Issue Date: 2015-05-19)
  9. US9091699B2: Microfluid testing system with a multiple-channel disc and utility thereof (Issue Date: 2015-07-28)
  10. US9254255B2: Dental care product with two-part formulations and utility thereof (Issue Date: 2016-02-09)
  11. US9346022B2: Antibiofouling composition, antibiofouling membrane and method for forming the same (Issue Date: 2016-05-24)
  12. US9393194B2: Biocarrier and method of using the same (Issue Date: 2016-07-19)
  13. US9522971B2: Amine modifying material and application thereof (Issue Date: 2016-12-20)
  14. US9598544B2: Particles coated with zwitterionic polymers comprising sulfobetaine or carboxybetaine (Issue Date: 2017-03-21)
  15. US11833289B2: Polymer and device for capturing or separating leucocytes, manufacturing method and use thereof (Issue Date: 2023-12-05)
  16. US12274987B2: Platelet filtration membrane and its applications thereof (Issue Date: 2025-04-15) 
  • Taiwan Patents
  1. TWI330657B: Super-low fouling carboxybetaine materials and related methods (Issue Date: 2010-09-21)
  2. TWI400285B: Method for Surface Modification of Substrate (Issue Date: 2013-07-01)
  3. TWI410269B: Leukocyte filter material and filter method thereof (Issue Date: 2013-10-01)
  4. TWI423843B: Low biofouling filtration membranes and their forming method (Issue Date: 2014-01-21)
  5. TWI423829B: Wound healing scaffold and method for fabricating the same (Issue Date: 2014-01-21)
  6. TWI425959B: Skin Wound Healing Material and Method for Manufacturing the Same (Issue Date: 2014-02-11)
  7. TWI428150B: Dental care product (Issue Date: 2014-03-01)
  8. TWM477285U: Blood Filtering Device (Issue Date: 2014-05-01)
  9. TWI452051B: Antibiofouling nonionic-zwitterionic copolymer (Issue Date: 2014-09-11)
  10. TWI496853B: Antibiofouling composition, antibiofouling membrane and method for forming the same (Issue Date: 2015-08-21)
  11. TWI496819B: Biomimetic agent for anti-biofouling coating and method for making the same (Issue Date: 2015-08-21)
  12. TWI509066B: Testing microfluid system with a multiple-channel disc and utility thereof (Issue Date: 2015-11-21)
  13. TWI522161B: Antifouling Membranes for Water Treatment Application Thereof (Issue Date: 2016-02-21) TWI541032B: Surface anti-biomolecule agent (Issue Date: 2016-07-11)  
  14. TWI549974B: Amine modifying material and application thereof (Issue Date: 2016-09-21) TWI559971B: A method for blood cell selection (Issue Date: 2016-12-01)  
  15. TWI602915B: Stem Cell Culture Device, Method of Fabrication, and Method for Partial Detachment of Stem Cells (Issue Date: 2017-10-21)
  16. TWI661864B: Polymer and device for capturing or separating leucocytes, manufacturing method and use thereof (Issue Date: 2019-06-11)
  17. TWI800039B: A Bio-inert Material and its Application in a Method for Reducing Biomolecular Adsorption on Metal Surfaces (Issue Date: 2023-04-21)
  18. TWI871196B: Thermo-induced stimuli-responsive membrane for leukocyte enrichment and application thereof (Issue Date: 2025-01-21)
  • Europe Patents
  1. EP1924654B1: Super-low fouling sulfobetaine and carboxybetaine materials and related methods (Issue Date: 2020-05-06)
  2. EP3095502B1: Double-ion charge deviation-type material for blood cell screening and method for removing leukocytes from blood sample (Issue Date: 2021-01-20)
  • Japan Patents
  1. JP6085075B2: Ultra-low fouling sulfobetaine and carboxybetaine materials and related methods (Issue Date: 2011-02-22)
  2. JP6457627B2: Double-ion charge deviation-type material for blood cell screening and method for removing leukocytes from blood sample (Issue Date: 2019-01-23)
  • China Patents
  1. CN102397724B: Leukocyte filter material and filter method thereof (Issue Date: 2014-08-20)
  2. CN103913562B: Microfluid testing system with a multiple-channel disc and utility thereof (Issue Date: 2016-06-29)
  3. CN109963600B: Polymer and device for capturing or separating leucocytes, manufacturing method and use thereof (Issue Date: 2023-01-06)

Technology Transfer & Licensing

  1. High-sensitivity virus capture technology
  2. Leukocyte separation technology
  3. Anti-biomolecular surface adhesion technology
  4. Polyolefin surface coating technology for stainless steel guidewires Pharmaceutical-grade coated butyl rubber stopper technology   Nanocellulose technology for hemostatic materials
  5. Composition and manufacturing technology for anti-adhesion copolymers
  6. Medical-grade polymeric membrane technology for the separation and purification of platelet-derived growth factors
  7. Biomimetic moisturizing membrane materials technology
  8. Development technology for critical raw materials of membranes
  9. Materials, methods, material manufacturing methods, filters, and applications thereof for leukocyte separation
  10. Blood purification technology
  11. Wound dressing technology
  12. Functional membrane coating technology
  13. Zwitterionic fluorinated materials for wound healing technology
  14. Amphiphilic Teflon wound dressing technology
  15. Porous fluorinated materials for wound healing technology
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