Professional Specialty：

• Biointerfacial engineering
• Biosensors
• Lipid membrane platforms

Research Fields：

1. Development of cell membrane platforms to separate cell membrane proteins, and introducing the chemical separation processes into the two-dimensional cell membrane platforms.
2. Development of theoretical models and experimental verification methods to effectively estimate whether lipid bilayer membranes can be formed on specific substrates or electrodes.
3. Development of a sensing chip with both surface plasmon resonance and waveguide resonance to detect the transport behavior of cell membrane transport proteins.
4. Development of a two-dimensional field-effect transistor sensor chip to detect the interaction between cell membranes and drugs.
5. Development of cell membrane chip with Raman spectroscopy to detect environmental toxins or screen drugs.

Potential Applications of Research：

1. Fundamental studies of cell membrane proteins
2. Drug screening platform
3. Communication interface between biological and electronic components
4. Detection of environmental toxins

Honors：

• LYC Outstanding Young Professor Award for Academic Research (2022)
• Taiwan Outstanding Female Scientist Rookie Award (2018)
• National Taiwan University Teaching Excellence Award (2017)
• Outstanding Talents Foundation Young Scholars Innovation Award (2016)
• Distinguished Lectureship Award by the Chemical Society of Japan (2016)
• Taiwan Chemical Engineering Society Academic Incentive Award (2015)
• Taiwan Chemical Engineering Society Chemical Masterpiece Award (2015)

Selected Publications：

1. Jiali Chen, Che-lun Chin, Qingzhen Zhu, Ling Chao* and Kaori Sugihara*, Deep Learning Enables Identification of Antimicrobial Peptides Through Mechanochromic Fingerprints, Chem. Int. Ed., 2026 , e5828776
2. Che-Lun Chin, Chia-En Chang, and Ling Chao*, Interpretable Multiscale Convolutional Neural Network for Classification and Feature Visualization of Weak Raman Spectra of Biomolecules at Cell Membranes, ACS Sensors, 2025, 10, 2652−2666
3. TT Liu, SH Huang, Ling Chao*, Rapid Enrichment of a Native Multipass Transmembrane Protein via Cell Membrane Electrophoresis through Buffer pH and Ionic Strength Adjustment, Journal of the American Chemical Society, 2024, 146, 11634−11647
4. Z Cui, CL Chin, AF Kurniawan, CC Huang, LT Huang, Ling Chao*, Size-selective adhesion of calcium oxalate monohydrate crystals to lipid membranes, Journal of Materials Chemistry B, 2024, 12 (9), 2274-2281
5. Chia-Wei Kuo , Tse-Han Kuo , Hui-An Lee , Yu-Ting Lin , Cheng-Jung Kuo , Kai-Hung Hsiao , Meng-Hua Yang , Kevin Tanady , Shu-Yu Chang , Tzy-Rong Lin , Ling Chao*, Label-free detection of transport kinetics and inhibitor binding of membrane transport proteins with a two-mode plasmonic sensor, Biosensors and Bioelectronics: X, 2022, Volume 11, 100183
6. Sin-Han Huang, Bo-Chuan Huang, and Ling Chao*, Development of Cell Membrane Electrophoresis to Measure the Diffusivity of a Native Transmembrane Protein, Analytical Chemistry, 2022, 94, 10, 4531–4537 (SCI, Chemistry, Analytical, 8/87, IF: 7.0)
7. Yu-Shan Chang, Hao-Cin Yang, and Ling Chao*, Formation of Supported Thylakoid Membrane Bioanodes for Effective Electron Transfer and Stable Photocurrent, ACS Applied Materials & Interfaces, 2022, 14, 19, 22216–22224 (SCI, Multidisciplinary, 44/334, IF=9.2)
8. U-Ting Chiu, and Ling Chao*, Electron transfer through protein-bound water and its bioelectronic application. Biosensors and Bioelectronics, 2019, 136, 16-22 (SCI, Biophysics, 2/74, IF: 10.6)
9. Shu-Kai Hu, Fang-Yen Lo, Chih-Chen Hsieh, and Ling Chao*, Sensing Ability and Formation Criterion of Fluid Supported Lipid Bilayer Coated Graphene Field-Effect Transistors. ACS Sensor, 2019, 4 (4), 892–899 (SCI, Chemistry, Analytical, 6/87, IF: 7.7) (featured on the cover page of Volume 4, Issue 4, 2019)
10. U-Ting Chiu, Bo-Fan Lee, Shu-Kai Hu, Ting-Feng Yu, Wen-Ya Lee*, and Ling Chao*, “Graphene Memory Based on a Tunable Nanometer-Thin Water Layer”, J. Phys. Chem. C, 2019, 12317, 10842-10848 (SCI, Materials Science, Multidisciplinary 54/285, IF: 4.5) (featured on the cover page of Volume 123, Issue 17, 2019)
11. Shao-Wei Lyu, Jou-Fang Wang, and Ling Chao*, Constructing Supported Cell Membranes with Controllable Orientation. (2019) Scientific Reports volume 9: 2747 (SCI, IF: 4.12)
12. Yu-Ling Shih*, Ling-Ting Huang, Yu-Ming Tu, Bo-Fan Lee, Yu-Chiuan Bau, Chia Yee Hong, Hsiao-lin Lee, Yan-Ping Shih, Min-Feng Hsu, Zheng-Xin Lu, Jui-Szu Chen, and Ling Chao*, “Active Transport of Membrane Components by Self-Organization of the Min Proteins”, Biophysical Journal, 2019, 116, 1469–1482 (SCI, IF: 3.5) (featured on the cover page of Volume 116, Issue 8, 2019)
13. Po-Chieh Chiang, Kevin Tanady, Ling-Ting Huang, and Ling Chao*, “Rupturing Giant Plasma Membrane Vesicles to Form Micron-sized Supported Cell Plasma Membranes with Native Transmembrane Proteins”, Scientific Reports, 2017, 7: 15139, p1-p8 (SCI, IF: 4.1)
14. B Lin, S Tsao, Alex Chen, Shu-Kai Hu, Ling Chao, and PG Chao*, “Lipid rafts sense and direct electric field-induced migration”, Proceedings of the National Academy of Sciences(PNAS), 114 (32), 8568-8573 (SCI, IF: 9.7)
15. Ling-Ting Huang and Ling Chao*, “The flow patterning capability of localized natural convection”, Chem. Chem. Phys., 2016, 18, 25380-25387 (SCI, IF: 4.45)
16. Shu-Kai Hu, Ling-Ting Huang and Ling Chao*, “Membrane species mobility under in-lipid-membrane forced convection”, Soft Matter, 2016, 12, 6954-6963 (SCI, IF: 3.8)
17. Chia Yee Hong, Chung-Ta Han, and Ling Chao*, “Nonspecific Binding Domains in Lipid Membranes Induced by Phospholipase A2”, Langmuir, 2016, 32 (27), 6991–6999 (SCI, IF: 4.3)
18. Chung-Ta Han and Ling Chao*, “Using a Patterned Grating Structure to Create Lipid Bilayer Platforms Insensitive to Air Bubbles”, Lab on a chip, 2015, 15(1), 86-93 (SCI, IF: 5.75) (featured on the front cover page of issue 1, 2015 and selected as a hot article in 2014 in Lab on a Chip, top 10% journal in biochemical research method category, SCI)
19. Po-Yu Peng, Po-Chieh Chiang, and Ling Chao*, ”Mobile Lipid Bilayers on Gold Surfaces through Structure-Induced Lipid Vesicle Rupture”, Langmuir, 2015, 31(13), 3904-3911 (SCI, IF: 4.3)
20. Chung-Ta Han and Ling Chao*, “Creating Air-Stable Supported Lipid Bilayers by Physical Confinement Induced by Phospholipase A2”, ACS Appl. Mater. Interfaces, 2014, 6(9), 6378-6383 (SCI, IF: 5.9)
21. Po-Yu Peng, Po-Chieh Chiang, and Ling Chao*, “Controllable Occurrence of Free-Standing Lipid Membranes on Nanograting Structured Supports”, ACS Appl. Mater. Interfaces, 2014, 6(15), 12261-12269 (SCI, Materials Science, IF: 5.9)
22. Shu-Kai Hu, Ya-Ming Chen and Ling Chao*, “Phase Segregation of Polymerizable Lipids to Construct Filters for Separating Lipid-membrane- embedded Species”, Biomicrofluidics, 2014, 8, 052005 (1-11) (SCI, IF: 3.77)
23. Charng-yu Lin, and Ling Chao*, ”Tunable Nucleation Time of Functional Sphingomyelinase-Lipid Features Studied by Membrane Array Statistic Tool”, Langmuir, 2013, 29(42), 13008-13017 (SCI, IF: 4.3)
24. Shu-Kai Hu, Sheng-Wen Hsiao, Hsun-Yen Mao, Ya-Ming Chen, Yung Chang and Ling Chao*, “Using Crosslinkable Diacetylene Phospholipids to Construct Two-dimensional Packed Beds in Supported Lipid Bilayer Separation Platforms”, Sci. Technol. Adv. Mater., 2013, 14, 044408 (1-8) (SCI, IF:3.75)