Prof. Juin-Yih Lai, Founder

Prof. Kueir-Rarn Lee

Prof. Chung-Jung Chuang

Prof. Yung Chang

Prof. Tsair-Wang Chung

Prof. Jung-Hui Chen

Prof. Shia-Chung Chen
Prof. Sheng-Jie You

Prof. Chien-Chieh Hu

Prof. Meng-Hui Li

Prof. Chia-Her Lin

Prof. Yi-Feng Lin

Prof. Hui-An Tsai

Assoc.Prof.Ta-Chin Wei

Assoc.Prof.Antoine Venault

Assoc.Prof.Wei-Song Hung

Prof. Da-Ming Wang

Prof. Duu-Jong Lee

Prof. Kuo-Lun Tung
Prof. Ying-Ling Liu

Chair Prof. Akon Higuchi

Prof. Yi-Ming Sun
Prof. Shing-Jiang Lue
Prof. Shu-Hsien Huang
Dr. Feng-Ming Ho
 

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Prof. Yung  Chang      {Deputy Director}

Ph.D., Chem. Eng., National Taiwan University  
E-mail
changyung0307@gmail.com

 Awards

2010 Young Investigator Award of Chemical Engineering

    (Taiwan Institute of Chemical Engineers)

 

2010 Young Investigator Award of Materials on Regenerative Medicine

    (National Health Research Institutes, Taiwan)

 

2011 Outstanding Research Professor Award (Chung Yuan Christian University, Taiwan)

 

2011 Outstanding Research Award of Chemical Engineering(LCY Chemical Corp.,Taiwan)

 

2012 NSC Wu Da-Yu Award (National science council, Taiwan)

 

2012 NSC Outstanding Academic/Industrial Cooperation Award (National science council)

 

2013 Young Investigator Award of Polymer Science (Taiwan Institute of Polymer Science)

 

2013 Distinguished Lectureship Award  (Japan Chemical Society)

 

2013 Distinguished Professor Award  (Chung Yuan Christian University, Taiwan)


Professional Speciality

Biomaterials and Biomolecular Engineering

Biomedical Interface Science

Biopolymer Physical Chemistry

Biomimetic Material Science

Blood Separation Technology

 Research Fields

Membrane Separation:

The major research fundamentals focus on the control of protein adsorption behavior from the chemical properties and physical structures of membrane surface. We currently concentrate on the development of low-fouling membranes for protein separation and water treatment.

 

Biomaterials and Biomolecular Engineering:

Our present interest lies on studying the non-fouling mechanism of biomaterials to biomolecules (protein, cell and tissues). The next step is to design and prepare polymeric materials with anti-fouling functionality and nano-carriers with specific recognition property.

 

Molecular Simulation:

The present research concentrates on two major efforts: (1) For biomolecular systems, we examine the mechanism of interracial molecular interactions (specific binding and nonspecific adsorption) between biomolecules and a material surface. (2) For polymeric systems, we study the fundamentals of polymer phase behaviors and build the control mechanism of morphology transformations.


Potential Applications of Research

Concentration and Separation of Bio-products

Surface Property Control for Biomaterials

Design of Bio-chip for Specific Recognition of Biomolecular Binding

Develop Functional Polymeric Materials for Anti-Fouling Performance

 


Selected Publications:

Jheng-Fong Jhong, Antoine Venault, Lingyun Liu, Jie Zheng, Sheng-Han Chen, Akon Higuchi, James Huang, Yung Chang  “Introducing Mixed-Charge Copolymers As Wound Dressing Biomaterials”, ACS Appl. Mater. Interfaces, 6, 9858–9870 (2014).

Y. Chang, Y.J. Shih, C.J. Lai, H.H. Kung, S, Jiang,  “Ion-pair anchoring of self-assembled zwitterionic copolymer surfaces with highly controlled blood compatibility”, Advanced Functional Materials, 23, 1100-1110 (2013).

Y.J. Shih, Y. Chang, A. Deratani, Q. Damien, “ "Schizophrenic" hemocompatible copolymers via switchable thermoresponsive transition of nonionic/zwitterionic block self-assembly in human blood”, Biomacromolecules, 13, 2849−2858 (2012).

Y. Chang, W.J. Chang, Y.J. Shih, T.C. Wei, G.H. Hsiue, “Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride) membrane with improved blood compatibility via atmospheric plasma-induced surface copolymerization”, ACS Appl. Mater. Interfaces, 3, 1228-1237 (2011).

Y. Chang, S.H. Shu, C.W. Chu, Y.J. Shih, R.C. Ruaan, W.Y. Chen, "Hemocompatible mixed-charge copolymer rushes of pseudo-zwitterionic surfaces resistant to nonspecific plasma protein fouling," Langmuir, 26, 3522-3530 (2010).

Y. Chang, W.Y. Chen, W. Yandi, Y.J. Shih, W.L. Chu, Y.L. Liu, R.C. Ruaan, A. Higuchi, “Dual-thermoresponsive phase behavior of blood compatible zwitterionic copolymers containing nonionic poly(N-isopropyl acrylamide),” Biomacromolecules, 10, 2092-2100 (2009).

Y. Chang, S.C. Liao, A. Higuchi, R.C. Ruaan, C.W. Chu, W.Y. Chen, “A highly stable nonbiofouling surface with well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion,” Langmuir, 24, 5453-5458 (2008).

Y. Chang, S. Chen, Q. Yu, Z. Zhang, M. Bernards, S.Y. Jiang, “Development of biocompatible interpenetrating polymer networks containing a sulfobetaine-based polymer and a segmented polyurethane for protein resistance,” Biomacomolecules, 8, 122-127 (2007).

Y. Chang, S. Chen, Z. Zhang, S.Y. Jiang, “Highly protein-resistant coatings from well-defined diblock copolymers containing sulfobetaines,” Langmuir, 22, 2222-2226 (2006).

  Tel +886-3-265-4190

Fax+886-3-265-4198

Emailmembrane@cycu.edu.tw

Address

No.493, Xinzhong N. Rd., 

Zhongli Dist., Taoyuan City 320,

Taiwan (R.O.C.)