Prof. Yung Chang
Ph.D., Chem. Eng.,
National Taiwan University
2010 Young Investigator Award of Chemical Engineering
(Taiwan Institute of Chemical
2010 Young Investigator Award of Materials on
(National Health Research
2011 Outstanding Research Professor Award (Chung
Yuan Christian University, Taiwan)
2011 Outstanding Research Award of Chemical
Engineering(LCY Chemical Corp.,Taiwan)
2012 NSC Wu Da-Yu Award
2012 NSC Outstanding Academic/Industrial
(National science council)
2013 Young Investigator Award of Polymer Science
(Taiwan Institute of Polymer Science)
2013 Distinguished Lectureship Award
2013 Distinguished Professor Award
Christian University, Taiwan)
and Biomolecular Engineering
The major research fundamentals focus on the
control of protein adsorption behavior from the
chemical properties and physical structures of
membrane surface. We currently concentrate on
the development of low-fouling membranes for
protein separation and water treatment.
and Biomolecular Engineering:
Our present interest lies on studying the
non-fouling mechanism of biomaterials to
biomolecules (protein, cell and tissues). The
next step is to design and prepare polymeric
materials with anti-fouling functionality and
nano-carriers with specific recognition
The present research concentrates on two major
efforts: (1) For biomolecular systems, we
examine the mechanism of interracial molecular
interactions (specific binding and nonspecific
adsorption) between biomolecules and a material
surface. (2) For polymeric systems, we study the
fundamentals of polymer phase behaviors and
build the control mechanism of morphology
Potential Applications of Research：
Concentration and Separation of Bio-products
Surface Property Control for Biomaterials
Design of Bio-chip for Specific Recognition of
Develop Functional Polymeric Materials for
Jheng-Fong Jhong, Antoine Venault, Lingyun
Liu, Jie Zheng, Sheng-Han Chen, Akon
Mixed-Charge Copolymers As Wound
Dressing Biomaterials”, ACS Appl. Mater.
Interfaces, 6, 9858–9870 (2014).
Y. Chang, Y.J. Shih, C.J. Lai, H.H.
Kung, S, Jiang, “Ion-pair anchoring of
self-assembled zwitterionic copolymer
surfaces with highly controlled blood
compatibility”, Advanced Functional
Materials, 23, 1100-1110 (2013).
Y.J. Shih, Y. Chang, A. Deratani, Q.
Damien, “ "Schizophrenic" hemocompatible
copolymers via switchable
thermoresponsive transition of nonionic/zwitterionic
block self-assembly in human blood”,
Biomacromolecules, 13, 2849−2858
Y. Chang, W.J. Chang, Y.J. Shih, T.C.
Wei, G.H. Hsiue, “Zwitterionic
fluoride) membrane with improved blood
compatibility via atmospheric
copolymerization”, ACS Appl. Mater.
Interfaces, 3, 1228-1237 (2011).
Y. Chang, S.H. Shu, C.W. Chu, Y.J. Shih,
R.C. Ruaan, W.Y. Chen, "Hemocompatible
mixed-charge copolymer rushes of pseudo-zwitterionic
surfaces resistant to nonspecific plasma
protein fouling," Langmuir, 26,
Y. Chang, W.Y. Chen, W. Yandi, Y.J.
Shih, W.L. Chu, Y.L. Liu, R.C. Ruaan, A.
Higuchi, “Dual-thermoresponsive phase
behavior of blood compatible
zwitterionic copolymers containing
nonionic poly(N-isopropyl acrylamide),”
Biomacromolecules, 10, 2092-2100
Y. Chang, S.C. Liao, A. Higuchi, R.C.
Ruaan, C.W. Chu, W.Y. Chen, “A highly
stable nonbiofouling surface with
well-packed grafted zwitterionic
polysulfobetaine for plasma protein
repulsion,” Langmuir, 24,
Y. Chang, S. Chen, Q. Yu, Z. Zhang, M.
Bernards, S.Y. Jiang, “Development of
biocompatible interpenetrating polymer
networks containing a sulfobetaine-based
polymer and a segmented polyurethane for
protein resistance,” Biomacomolecules,
8, 122-127 (2007).
Y. Chang, S. Chen, Z. Zhang, S.Y. Jiang,
“Highly protein-resistant coatings from
well-defined diblock copolymers
containing sulfobetaines,” Langmuir,
22, 2222-2226 (2006).